Evaluation of the informative value of diagnostic methods in determining the etiology of ED

Diagnostic ED: A large number of research papers on the physiology of erection and the pathophysiology of erectile dysfunction have been published, which have revealed the problem of studying the informativeness of diagnostic methods aimed at identifying the etiology of ED.

Currently, due to the wide choice of laboratory and instrumental diagnostic methods, the question arises about their irrational use, since some of them have insufficient information content and do not have diagnostic significance, and therefore do not play a special role in determining the further tactics of managing patients with erectile dysfunction. At the same time, it should be noted that the strategy for treating ED depends on the effectiveness and timeliness of diagnostic measures, and the delay in finding the causes of erectile disorders negatively affects the effectiveness of therapy.

To establish the etiopathogenetic mechanism of ED development, a comprehensive integrative approach is used, which implies step-by-step laboratory and instrumental studies. However, this does not always make it possible to obtain reliably significant information necessary for making a decision on the further plan of therapeutic and diagnostic measures.

The determination of diagnostic parameters that are highly specific and sensitive in determining the etiology of ED will reduce the frequency of unnecessary diagnostic measures and increase the accuracy of the really necessary diagnostic methods, which means that the optimal therapeutic tactics will be chosen.

Purpose of the study: To evaluate the informativeness of the diagnostic parameters used in determining the etiology of ED.

Materials and methods diagnostic ED

The study involved 465 men who complained about the inability to achieve and maintain an erection sufficient for sexual intercourse. The median age of the patients was 39 (30-49 years). The study did not include patients with cancer, autoimmune, or mental illnesses identified during the examination.

All participants underwent a step-by-step comprehensive diagnosis, including a clinical and anamnestic examination, a questionnaire (according to the questionnaire of the international index of erectile function 15), a physical and laboratory-instrumental examination. The results of a biochemical blood test (total protein, total bilirubin, creatinine, urea, alanine aminotransferase, aspartate aminotransferase, glucose) were evaluated with the determination of lipid (total cholesterol, high-and low-density lipoprotein cholesterol, triglycerides) and hormonal (total testosterone, sex hormone-binding globulin, estradiol, prolactin, and thyroid-stimulating hormone) profiles.

All patients underwent pharmacodopplerographic examination of the vessels of the penis using intracavernous injections of prostaglandin E1 (none of the patients had contraindications to this procedure). Diagnostic parameters such as the peak systolic blood flow rate in the cavernous arteries (Vmax a. cavernosa), the final diastolic blood flow rate in the cavernous arteries (Vend a. cavernosa), the index of resistance of the cavernous arteries, as well as the maximum speed and time of preservation of blood flow in the deep dorsal vein were evaluated.

diagnostic ED

All patients also underwent a non-invasive examination of the endothelial system function using a special EndoPat hardware complex with the determination of the value of the reactive hyperemia index, which allows us to assess the presence or absence of endothelial dysfunction.

Based on the results of the examination, the patients were divided into two groups for a consistent statistical analysis. The first group included 319 (68.6%) men with diagnosed organic forms of ED, the median age was 44 years. The second group included 146 (31.4%) men who had confirmed ED that was not associated with organic factors, the median age was 30 years.

Results

According to the results of the study, diagnostic parameters that are sufficiently informative make it possible to timely identify risk factors and pathological conditions underlying the etiology of ED, avoiding overdiagnosis. Diagnostic parameters that have unsatisfactory information content can be conditionally considered as additional if appropriate clinical data are available.

Through the consistent use of informative diagnostic parameters, it is possible to establish risk factors, as well as concomitant somatic diseases that are associated with the development of organic forms of ED, in order to determine further therapeutic and diagnostic tactics.

Tadalafil in the treating of erectile dysfunction

Erectile dysfunction (ED) is the inability to achieve or maintain an erection that allows for coitus. In more than 67% of men, the deterioration in the quality of sexual life occurs due to erectile dysfunction. The prevalence of the disease correlates with age. ED is detected in 40% of men aged 40-50 years, in 57% – at the age of 50-60 years and in 70% – over 60 years. It is expected that by 2025, more than 300 million men will suffer from erectile dysfunction. When determining the treatment strategy, it should be taken into account that 31.5-44% of the male population remain sexually active until the age of 80. Consider the treating of erectile dysfunction on the example of tadalafil.

To date, the first-line drugs for ED therapy are phosphodiesterase type 5 inhibitors (PDE-5), which have been used for the treatment of erectile dysfunction since 1998.

During sexual stimulation, the parasympathetic nervous system is first activated, after which a relaxing factor – nitric oxide-is released from the vascular endothelium, which leads to the accumulation of cyclic guanosine monophosphate in the cavernous tissue and relaxation of the walls of the fetal arteries and cavernous bodies. The result of the active filling of the cavernous bodies of the penis with arterial blood is the compression of the venules, which allows you to block the outflow of blood, thereby provoking the appearance of an erection. It is important to note that when the intracellular activity of PDE-5 is suppressed, even a slight activation of guanylate cyclase can cause a sharp increase in the concentration of cyclic guanosine monophosphate inside the cell. As a result, the tone of the smooth muscle framework of blood vessels decreases with a further drop in blood pressure. That is why the use of nitrates is contraindicated in the appointment of PDE-5 inhibitors.

There are currently four PDE-5 inhibitors on the market: sildenafil, tadalafil, vardenafil, and udenafil. Speaking about the pharmacodynamic properties of these drugs, it is necessary to note the selectivity of their effect on PDE. Thus, sildenafil and vardenafil have similar selectivity for PDE-5. In addition, they have a weak depressing effect on PDE-1 and 6. It is known that blocking PDE-6 can provoke color perception disorders. Exposure to PDE-1 leads to side effects from the cardiovascular system. In contrast to other drugs of the discussed group, the affinity of tadalafil for PDE-1 is significantly weaker. It has been proven that this drug, which is highly selective against PDE-5, inhibits PDE-6 to a lesser extent, which minimizes the likelihood of side effects, in particular from the side of vision.

At the same time, the tadalafil molecule has a high affinity for PDE-11, which is found in muscle tissue. For this reason, patients taking tadalafil are more likely to have myalgia and back pain. However, daily intake of tadalafil in low doses (2.5–5 mg) can reduce the frequency and severity of headache, nausea, dizziness, myalgia, and redness of the face by three to five times compared to its on – demand intake at a dose of 10-20 mg. The low level of side effects of tadalafil is due to the long half-life of the drug, which allows it to be used in low doses. A number of studies have revealed the absence of serious side effects on the background of daily intake of tadalafil. In addition, it was found that against the background of long-term use of tadalafil, the frequency of side effects significantly decreased over time.

S. McMahon and co-authors analyzed the results of treating of erectile dysfunction. Of the 70 men who took taladafil (20 mg) on demand, 73% gave responses indicating a significant improvement in the quality of an erection. According to D. Hatzichristou and co-authors, patients suffering from diabetes mellitus also noted an improvement in erectile function against the background of daily tadalafil intake without pronounced changes in the level of glycated hemoglobin.

treating of erectile dysfunction

In addition to the advantages characteristic of the entire class of PDE-5 inhibitors, tadalafil has a number of unique properties. Its half-life is 17.5 hours, which provides more than 36 hours of drug action. This duration is especially relevant for young patients with high sexual activity. Daily intake of tadalafil (5 mg) allows you to maintain the therapeutic level of the drug in the body of a man, sufficient to preserve the spontaneity of sexual life and does not require prior planning of sexual intercourse. It was found that 79.2% of women preferred their partner to take tadalafil rather than sildenafil, citing a more comfortable approach to sexual contact and intimacy. Thus, the spontaneity of sexual life against the background of daily therapy with tadalafil is an important and attractive factor for most partners of men suffering from erectile disorders. In another study, it was shown that the constant intake of tadalafil 5 mg / day as an effective method of treating ED satisfied both men and their sexual partners.

Treating of erectile dysfunction – Conclusion

Thus, tadalafil in comparison with other representatives of the group of PDE-5 inhibitors has a number of undeniable advantages. First of all, this is due to the duration of its action, due to the long half-life of the drug. The constant concentration of the drug in the blood allows you to maintain the spontaneity of sexual contacts, which, of course, has a positive impact on the quality of life of both patients and their partners. In addition, tadalafil is presented in various dosages, which makes it possible to use the drug daily, increases adherence to treatment with a reduced likelihood of side effects.

Experience in the use of alpha-lipoic acid in the treatment of erectile disorders in patients with diabetes mellitus

Alpha-lipoic acid in the treatment of erectile: To date, there are more than 250 million patients with diabetes mellitus, a chronic non – communicable disease with a pandemic growth rate, in the world alone. At the same time, about 50% of all patients with diabetes are patients of the most active and working age (40-59 years).

Experts of the International Diabetes Federation predict that the number of such patients will increase by one and a half times by 2025 and reach 380 million, mainly due to type 2 diabetes. Data from control and epidemiological studies conducted by the Endocrinology Research Center from 2002 to 2009 indicate that the real number of patients with diabetes is two to three times higher than the registered one and amounts to about 9 million people.

Alpha-lipoic acid in the treatment of erectile dysfunction

The prevalence of erectile dysfunction – a permanent inability to achieve and maintain an erection sufficient for successful sexual intercourse, among diabetic patients, according to various studies, ranges from 20 to 85%. Having diabetes increases the risk of erectile dysfunction by two to four times compared to healthy men of the same age.

In total, about 75% of men with the disease sooner or later notice erectile dysfunction, while such disorders occur in them much earlier than in healthy men, are more severe and more reduce the quality of life. The age of patients, the duration of the course of diabetes, the severity of metabolic disorders (uncontrolled glycemia, hyperlipidemia), the presence of diabetic neuropathy, retinopathy, nephropathy, macroangiopathy are important risk factors for the development of erectile dysfunction in people with diabetes and no viagra can help here.

The role of alpha-lipoic acid drugs in the treatment of erectile dysfunction

For a long time, various preparations of an endogenous antioxidant – alpha-lipoic acid, which is formed during the oxidative decarboxylation of alpha-keto acids, have been successfully used in practical healthcare in Russia. The antioxidant effect of alpha-lipoic acid is due to the presence of two thiol groups in the molecule, the ability to bind free radicals and free tissue iron and prevent its participation in lipid peroxidation.

The property of normalization of cellular metabolism is realized by direct inactivation of free radicals due to their binding by SH-groups of alpha-lipoic acid. The acid not only has its own antioxidant potential, but also provides powerful support for other antioxidant links in the body. Its protective effect is closely related to homeostasis in the system of glutathione and ubiquinone. Alpha-lipoic acid also enhances the anti-inflammatory effects of glucocorticosteroids. In addition, this acid is similar in pharmacological properties to B vitamins, as a result of which it is able to reduce blood glucose levels (the effect of glucose utilization) and increase the content of glycogen in the liver.

alpha-lipoic acid in the treatment of erectile

Of particular interest are the results of a recent study of the effectiveness of alpha-lipoic acid in patients with type 2 diabetes and erectile dysfunction, conducted at the Research Institute of Urology. Alpha-lipoic acid was administered at a dose of 600 mg / day and the parameters of erectile function, libido, and symptoms of androgen deficiency were evaluated. The study involved 86 men aged 43 to 59 years (mean age 51 years) with compensated (HbA1c < 7%) type 2 diabetes and erectile dysfunction. 52 men of the main group received alpha-lipoic acid. The control group consisted of 34 patients.

The effectiveness of treatment was evaluated 12 weeks after the appointment of alpha-lipoic acid based on the completion of the validated ICEF-5 scale and the questionnaire of age – related symptoms of men (Aging Male Simptoms-AMS). When analyzing the results of the study, the patients of the main group showed a significant increase in the sum of ICEF-5 scores from 18 (13-21) to 22 (20-24) and a decrease in the AMS score from 42 (35-44) to 33 (29-34) compared to the control group, where there were no significant changes in the scores according to the questionnaires.

The researchers believe that taking into account the positive pathogenetic effect of alpha-lipoic acid on the endothelium of the cavernous arteries, as well as on the cavernous nerves, new possibilities for its use in the treatment of erectile dysfunction in patients with DM and other forms of erectile dysfunction, taking into account the general mechanisms of development.

Conclusion

Erectile dysfunction is an urgent problem for patients with diabetes – a widespread worldwide disease with a high growth rate. Pathogenetic therapy of erectile dysfunction in patients of this category necessarily implies compensation for DM and a decrease in the severity of symptoms of peripheral diabetic polyneuropathy.

For a long time, for the treatment of diabetic neuropathy, the administration of various alpha-lipoic acid drugs has been successfully practiced, which reduce the manifestations of oxidative stress – the leading factor in the pathogenesis of diabetes and its complications. The possibility of effective administration of alpha-lipoic acid in erectile dysfunction in patients with DM determines the relevance and prospects of its clinical use.

Pharmacotherapy of erectile dysfunction

Pharmacotherapy of erectile dysfunction: Erectile disorders are often the cause of reactive states, lead to loss of interest in life and even suicidal attempts, socially maladapt the personality. In 30-70% of cases, erectile dysfunction is the cause of depression.

Erectile disorders are not just a male problem. The “side effects” of this condition are also reflected in sexual partners. Among the women surveyed whose partners had erectile disorders, 60% reported a decrease in interest in sex compared to 29% of those with partners who did not have erectile disorders, 44% had problems with lubrication compared to 11% whose husbands did not have sexual problems, and 52% reported difficulties in achieving orgasm compared to 20% of women with partners without any sexual disorders.

The relevance of the problem of erectile disorders is undoubtedly related to the prevalence of this condition, which is clearly demonstrated by epidemiological and social studies conducted around the world.

50% of men worldwide over the age of 40 suffer from erectile disorders of varying severity: 30 million men in the United States, 31 million in Europe, 7-8 million in Russia, although the data is very understated. By 2025, the WHO predicts that 900 million men will suffer from erectile dysfunction. The largest increase is expected in developed countries, large industrial centers.

Back in 1940, Stekel wrote, warning that “impotence is a disease associated with modern civilization”, and the famous psychiatrist Ouden described our century as “an era of anxiety”. The widespread and steady growth of erectile disorders in the population has led the WHO to classify erectile dysfunction (ED) as one of the most important problems of our time. Moreover, in 2000, the WHO set of documents legally spelled out the “fundamental rights of citizens to sexual health”.

The progressive growth of erectile disorders is primarily due to the demographic situation in developed countries – the global aging of humanity, the increase in life expectancy in Europe and North America. Someone solves the problem with an erection with the help of Viagra, someone is not treated at all.

Also, the key points of this process are the growth rates of risk factors, the main of which are cardiovascular diseases and diabetes mellitus. According to a number of researchers, a steady increase by 2025. ED of up to 900 million people will be associated with a similar increase in the incidence of diabetes. The increase in the frequency of ED is also associated with population growth, mainly due to third world countries. The socio-economic factor is also key.

Trends in the growth of erectile disorders vary in different countries of the world, which is explained by the peculiarities of national and cultural traditions, the degree of development of the information base and a number of other factors.

Pharmacotherapy of erectile dysfunction: Therapy

Modern oral therapy is more than 40 years old. Pharmaceuticals differ in the target point and are divided into drugs of central and peripheral action. The mechanisms of action of non-hormonal drugs are different and are based on the blockade of a-adrenergic receptors (phentolamine, iohimbine), serotonergic receptors (trazodone), stimulation of dopaminergic receptors (apomorphine) and blockade of phosphodiesterases (Viagra, Levitra, Cialis). These groups of drugs can be used as a course of monotherapy or for the purpose of sexual adaptation (pharmacoprosthesis).

pharmacotherapy of erectile dysfunction

Despite the certain effectiveness of central-acting drugs, the prevalence of side effects over therapeutic, as well as the systemic effect at the central nervous system level, in our opinion, are a limiting factor for the widespread use of this group of drugs in the correction of ED.

The accumulated clinical experience currently allows specialists to take a more detailed approach not only to solving the problem of erectile disorders, but also to qualitatively change the sexual life of the patient as a whole, taking into account his needs and desires.

How smoking affects potency

Dear smokers, I have bad news for you. In fact, the naked truth that smoking affects potency in a negative way has been known for a long time. You yourself have definitely seen the warning labels and pictures on cigarette packs. Moreover, you may have heard the medical term “nicotine impotence”. Anyway, today I propose to talk about the connection between erectile dysfunction and smoking.

The effect of nicotine on male sexual function

Most men have real phobia of impotence. However, many imagine this diagnosis as a complete loss of erection. Meanwhile, in fact, erectile dysfunction most often manifests itself as insufficient firmness of the penis.

The condition of this male organ depends on a symbiosis of factors, including blood circulation. Obviously, smoking has a negative effect on blood vessels. Thus, smoking affects potency – indirectly and negatively.

First, nicotine causes the blood vessels to constrict. In addition, it provokes a spasm of the vascular walls. This, in turn, affects the arteries of the heart, blood vessels, lungs, as well as the penis. With prolonged abuse of nicotine, the structure of blood vessels and their ability to relax worsen, they lose former firmness and elasticity.

Some studies on the effect of smoking on potency

A number of studies have shown that the negative effects of smoking on blood vessels and sexual function are in most cases reversible. In other words, if you give up the bad habit, you can return to a normal erection over time. However, in order to speed up the process, better use the drugs for erectile dysfunction at the same time.

smoking affects potency

One of the scientific studies has shown that problems with potency attack more than half (53%) of smokers aged 40 to 47 years. By the way, smoking affects potency in different ways. In particular, men may complain of a weak erection, difficulty in maintaining it, early ejaculation, or, conversely, the inability to finish.

Scientists have also found that the likelihood of problems and their intensity correlate with smoking history. Men who smoke one pack of cigarettes a day are 60% more likely to develop impotence than non-smokers. For ex-smokers, the risk is 15% higher than for those who have never abused nicotine. Diagnosed impotence in smokers occurs 30% more often than in people without such bad habits.

Other effects of smoking and factors important for male health

Of course, smoking affects potency, but it also negatively influences the quality indicators of sperm. Smokers have a decrease in sperm count, spermatozoids become less mobile. So, if you want to not only enjoy quality sex, but also become a father, better quit smoking as soon as possible.

However, do not try to focus only on how smoking affects potency. Do not forget that other factors – a sedentary lifestyle, lack of physical activity, unhealthy diet, alcohol abuse, stress, and so on – also negatively affect male sexual power.

Impotence-causing medicines: A brief guide

Unfortunately, many men, especially with aging, face the problem of poor erection quality. Quite often, this happens due to impotence-causing medicines. With certain diagnosis, patients have to take them, thus risking their sexual health.

Below we will list some commonly used impotence-causing medicines which can trigger the onset of erectile dysfunction. At the same time, please mind that impotence occurs in a minor percentage of patients.

List of impotence-causing medicines

Let us divide the drugs in groups:

  • medicines for the treatment of arterial hypertension, diuretic drugs, centrally acting antihypertensives, α-blockers, β-blockers
  • drugs for the treatment of dyslipidemia (high triglycerides / cholesterol)
  • certain medications to treat heart failure
  • drugs for the treatment of neurological and psychiatric diseases, including lithium salts, haloperidol, chlorpromazine and barbiturates
  • medicines for the treatment of prostatic and endocrinological diseases, corticosteroids
  • certain drugs for gastroenterological diseases
  • drugs for the treatment of inflammatory and degenerative diseases of the osteo-articular system

In particular, such impotence-causing medicines can alter both the function of the hypothalamus-pituitary system and testicular steroidogenesis. Also, they can act by antagonizing the peripheral action of androgens. In any case, better see a doctor who may possibly prescribe you an alternative therapy.

Other risk factors for men

Besides the listed drug groups, mind other potentially harmful substances. For example, men may obtain erectile dysfunction due to drug (cannabis, cocaine, LSD etc.) abuse. In addition, drinking too much alcohol and smoking cigarettes can also aggravate the disorder. Moreover, alcohol abuse often leads to decreased libido and premature ejaculation.

impotence-causing medicines

Erectile dysfunction psychotherapy – the main things to know

According to some reports, approximately 40% of cases of impotence in men have psychological causes. Thus, many people need erectile dysfunction psychotherapy. Typically, this method brings to excellent results. At the same time, for greater success of treatment, better simultaneously switch to a healthier lifestyle. In addition, in the course of therapy, a man can use “doping” in the form of effective pills for impotence.

Why do men resort to erectile dysfunction psychotherapy?

Erection problems don’t just rob us of fulfilling lives and essential pleasures. Unfortunately, impotence can also lead to relationship problems and even family breakdown. Furthermore, insufficient or absent erection negatively affects the emotional state of a man in general. In turn, this causes a decrease in self-esteem and self-confidence, which can exacerbate anxiety or apathy. For many, erectile dysfunction psychotherapy is the only way out, along with the medicines such as Viagra.

erectile dysfunction psychotherapy

What stages can include psychotherapy for impotence?

Of course, each school and each specialist has its own treatment methods. Moreover, the program of erectile dysfunction psychotherapy usually depends on the individual characteristics of the patient. Finally, the duration and intensity of such therapy depend on the degree of erection problems. However, the most common practices involve several steps:

  • Building trust with the patient. Without sincere contact, the therapist will not be able to help you cope with difficulties in sex. In addition, reducing anxiety and distrust at the very beginning of the course helps to relax. This can positively affect both the effectiveness of psychotherapy and the sexual function itself.
  • Strengthening of personal protective mechanisms and formation of a positive life scenario. Also, at this stage of psychotherapy for erectile dysfunction, some specialists include body therapy in the program. Besides, to deal with acute stressful situations, the doctor may offer you hypnosis sessions.
  • Pair or family therapy. Even with noticeable success, the patient should think about joint sessions with a partner. Most often, an average couple needs just 5 to 10 sessions with a psychotherapist.

Additional tips for suffering from impotence

I should emphasize once again that men should better combine erectile dysfunction psychotherapy with other methods to improve potency. For example, if you have problems with erection, consider quitting smoking and reducing the amount of alcohol. Also, don’t forget about physical activity and a healthy diet. Of course, feel free to support yourself with ED pills if necessary. Every quality sex in case of psychogenic impotence will work for you.

Diseases to provoke erectile dysfunction (and those caused by it)

Today, I would like to briefly talk about the diseases which can provoke erectile dysfunction. Moreover, I will list the most common consequences of impotence in men. Yes, our body is designed in such a way that one disease can cause a second, and that, in turn, provoke a third.

Basic diagnoses – potential threats to potency

However, let’s start with diseases that can lead to difficulties with an erection in men of all ages. Of course, any person can easily solve such problems with the help of proper drugs. However, noticing the symptoms in time often helps to avoid real difficulties. If you manage to cure the underlying disease, erectile dysfunction may not occur.

The main diseases that provoke erectile dysfunction:

  • Endocrine diseases. Quite often, impotence occurs as a result of hormonal imbalance. Some men can recover sexual function by treating an underlying condition.
  • Diabetes. This disease affects not only hormones, but other bodily functions as well. As a result, many patients cannot naturally achieve a normal erection and keep it long enough. In this case, in addition to treating diabetes, doctors recommend choosing the appropriate dose of anti-ED medication.
  • Pathology of the heart and (or) blood vessels. In fact, these diseases are among the main ones to provoke erectile dysfunction. Moreover, the majority of effective drugs for impotence work primarily due to their effect on blood vessels.
  • Prostatitis. Unfortunately, this disease can both provoke erectile dysfunction and be a consequence of impotence. Anyway, check regularly and monitor your symptoms.
  • Sexually transmitted infections. Use condoms.
  • Mental illnesses and psychological problems. Even common stress and depression can trigger impotence. Also, don’t forget the importance of a healthy lifestyle.

provoke erectile dysfunction

What can impotence lead to?

After we have focused on the diseases that provoke erectile dysfunction, let’s talk about the opposite situation. What can impotence lead to, besides the lack of sex?

Impotence itself may be a symptom of other diseases, for example:

  • atherosclerosis
  • ischemia
  • increased risk of stroke
  • depression.

Take care of yourself!

Pandemic-related sexual problems

Today, I propose to discuss global pandemic-related sexual problems. Let us talk about the challenges that people around the world face due to COVID, how to improve sex in these hard times, and which new important rules to follow.

It has long been known (a study was conducted by one of the largest condom manufacturers in the world) that during the pandemic people spent in bed making love much less time than usually. Also, for obvious reasons, men and women almost everywhere had less sex. Due to lockdowns and social distancing, health fears and the growth of depressive moods our intimate lives got worth.

But I would like to mention some other pandemic-related sexual problems, too.

Some other pandemic-related sexual problems causes

First of all, the reason for less and worse sex lies in the psychological reasons. Due to the fear of infection and of the future in general, many people experience anxiety. In addition, many have both psychological and financial difficulties, which often lead to depression – another trigger of pandemic-related sexual problems. Unfortunately, you cannot figure it all out by vaccinating.

pandemic-related sexual problems

Also, when life gets this difficult, many people just don’t have time for sex. On the other hand, the lack of sex and emotional intimacy can lead to even greater depression. A vicious circle! So, what to do? First of all, seek intimacy despite the daily difficulties. In case of physiological problems with erection, take special medications.

The rules for safe and successful sex during the pandemic

Now, after talking about pandemic-related sexual problems, I’ll give you a few simple tips that will help enjoy safe, high-quality sex even these days:

  • Literally make an effort to forget all your worries and go back to your normal intimate life.
  • Ask your doctor for a prescription to purchase pills to improve erection quality, or search for them on the Internet, so that you can be ready for a sexual adventure whenever you need them.
  • Don’t have sex if you have a diagnosis or symptoms of the virus. During the recovery period, refrain from unnecessary stress and physical loads. Also, self-isolate in order not to infect anyone.
  • To avoid pandemic-related sexual problems, be even more careful in case of one-night stands. Avoid kissing, use protective equipment and contraception.
  • Do not forget that the virus spreads through all types of mucous membranes. So, take care not only of hand hygiene, but also of the whole body, including the genitals.

Why is Sildenafil better than other drugs for impotence?

Most men, at the first signs of impotence, choose taking medications based on Sildenafil. However, is Sildenafil better than other erectile dysfunction drugs? Let’s try to figure it out together.

Benefits of Sildenafil compared to other alike medicines

First of all, speaking about why is Sildenafil better than other similar medicines, I would like to mention its long-term use for the treatment of erectile dysfunction. Scientists invented other erectile dysfunction drugs much later (and still continue working on them), while Sildenafil has been helping men for decades. During this time, millions were able to make sure of the highest efficiency and amazing safety of this product.

In addition, Sildenafil seems much better than other medications in terms of speed and duration of action. First of all, these pills affect the erection quickly enough. You just have to take a pill, and then start petting right away, so that you can have excellent sex literally in half an hour or even earlier.

Sildenafil better than

Also note the duration of action of Sildenafil. Most men can have great erections and have sex continuously or several times within hours after taking the pill. In fact, most of us do not need longer erections.

Moreover, the medication works only at the moment when you get aroused and really want sex. In other words, erection won’t disturb you if do not need sex anymore.

Disadvantages of Sildenafil compared to some other means

Honestly, is Sildenafil always better than other medicines for impotence? No! For some men, other similar drugs might work better. First of all, I mean patients with severe erectile dysfunction. Such men need constant therapy with a long-term positive effect, and therefore prefer to take Cialis tablets.

I would like to note another advantage of Cialis. In other words, just one high-dose yellow pill can act for two days or even longer. That is why men who have sex rarely, but for a long time (for example, for the whole weekend), prefer this substance.

As for the long-term treatment of impotence with Cialis, it has certain disadvantages. In particular, you will have to take the pills every day, if possible at the same time. That is, you must constantly remember about the medicine, always carry it with you and do not forget to take it. Not everyone likes such an approach, so many men answer the question is Sildenafil better than other drugs, including Cilais, in an obvious way.