Category: Pharmaceutical news

Restoration of potency after transurethral resection

Transurethral resection of the prostate is a minimally invasive and effective operation that is prescribed to patients with benign prostatic hyperplasia. Despite the minimal invasiveness, this method is characterized by some complications, among which there is a violation of potency. This condition is quite a serious problem, especially for young men. Fortunately, the violation of potency can be temporary and with proper, professional treatment disappears after a certain time.

Why is potency disturbed after surgery

According to the results of numerous studies, it was found that up to 40% of patients who underwent transurethral resection of the prostate gland face erectile dysfunction of various degrees of severity. The exact causes of this complication have not yet been established, but scientists have several assumptions. The psychological factor is also not ignored. The experiences of a man before surgery on an important organ for him have a negative effect on the erection. This is also facilitated by the painful sensations after transurethral resection – some men noted that because of the postoperative pain when urinating, they are afraid to enter into an intimate relationship. However, after 3-6 months, when the pain went away, they had a complete recovery of the erection.

What should I do if potency has disappeared after transurethral resection?

First of all, you need to contact a competent specialist. Self-medication, the use of traditional medicine and other methods can significantly worsen the patient’s condition. Before you start to restore potency, you need to be diagnosed and determine the cause of its violation. To do this, you will need to go through several stages:

  1. Interview with a doctor, analyze complaints, collect anamnesis, study the details of the operation.
  2. Laboratory tests. The doctor may prescribe the determination of the level of hormones in the blood, etc.
  3. Instrumental examination. It may include such methods as transrectal ultrasound of the prostate gland, Dopplerography of the vessels of the penis.

Experts emphasize that a decrease in the quality of sexual life is quite common, especially in elderly patients who have undergone any manipulations on the prostate gland. Do not hesitate to visit the doctor and try to solve the problem yourself. This approach can only make the situation worse.

transurethral resection

How to restore an erection after transurethral resection of the prostate gland

Modern medicine can offer several ways to help restore potency. Treatment can be complex, or limited to only one method. The exact plan is always developed individually and may include:

  • LOD-therapy. This method allows you to increase blood circulation in the vessels of the penis, restore the destroyed nerve connections and reflex mechanisms that are involved in the occurrence and maintenance of potency, due to local negative pressure. The treatment is relatively simple, but requires a certain amount of time to achieve the result.
  • Shock-wave therapy. The efficiency of the method is about 70%. The procedure helps restore blood circulation in the cavernous bodies, accelerates tissue regeneration after surgery, and relieves inflammation and pain. Of course, all these processes have a positive effect on potency.
  • Drug therapy. It includes the appointment of special drugs in tablet form, as well as injections into the penis. The latter method is considered the most effective, although not the most pleasant.
  • Related procedures. The recovery process can be affected by the patient’s exercise and lifestyle. In particular, it is recommended to give up smoking and other bad habits, it is necessary to eat properly, to be in the fresh air more often, to lead a mobile lifestyle.

In exceptional cases, when conservative treatment does not bring the desired result, penile prosthetic surgery (phalloprosthesis) may be prescribed. It should be approached very carefully, especially in elderly patients.

Thus, there are various ways to restore potency after transurethral resection of the prostate. Initially, it is important to determine the cause of this problem and find out the individual characteristics of the patient. It is impossible to get such information on your own, so if you develop erectile dysfunction, you should contact a urologist-andrologist. The doctor will conduct an examination, prescribe the necessary diagnosis and select the optimal treatment plan, which will need to be strictly followed. Only if all these conditions are met, you can achieve the maximum chance of recovery.

December 10, 2022 / by Kevin Roberts

How does hirudotherapy help in matters of potency?

Hirudotherapy: The use of leeches for medical therapy. From hirudin, the active principle in the salivary secretion of leeches that acts as a potent anticoagulant (blood thinner).

hirudotherapy or viagra

Would you be able to treat yourself with leeches? Well, who’s brave?

Hirudotherapy within the framework of urology is becoming more popular year by year. More and more doctors are talking about the effectiveness of this type of treatment.

In urology, the indications for hirudotherapy are:

However, this is not all that such seemingly ordinary leeches help to cope with.

They solve such problems as pyelonephritis, cystitis, renal colic, low libido, hydronephrosis.

By the way, in the treatment of priapism and elephantiasis of the scrotum, leeches are almost the only treatment.

Well, where is it without potency! This is one of the main topics for men, and leeches and really well solve this issue. Why is this happening?

With the help of hirudotherapy, you can well improve blood circulation in the pelvic area. Blood completely fills the cavernous bodies of the sexual organ and there are no difficulties with potency. The effect of this procedure is visible almost immediately. Almost like after Viagra.

April 6, 2022 / by Kevin Roberts

Sexual dysfunction and social adaptation

Sexual dysfunction: The concept of “violation of sexual function” traditionally includes a whole range of problems: these are violations of sexual desire, sexual arousal and orgasm, as well as pain during sexual intercourse caused by both medical and psychological problems of a person. Usually, even one of these problems leads to the inability or unwillingness to lead a sexual life, which seriously affects the social role of a person. And believe me, no viagra will help here.

Lack of sexual activity is a serious problem in people’s relationships. According to studies conducted in America in the 70s, 35% of women and 15% of men under the age of 50 say that they do not want to have sex with their spouse, and among young (under 30) unmarried people, 8% complain about the lack of sexual life in the presence of a partner.

Sexual dysfunction: Reasons

Doctors identify many reasons for the lack of sexual activity in couples. Traditionally, they are divided into psychological and organic.

Psychological factors include factors that are tied to a person’s perception of the surrounding reality. Among the most common are::

  • self-doubt;
  • fear of contracting a sexually transmitted disease;
  • overwork;
  • constant voltage;
  • insomnia.

But in addition to this, the cause can be child psychological trauma, temperament properties, difficulties in relationships with people, and much more.

Organic factors are associated with innate or acquired features due to diseases. They are associated with the physical inability to perform sexual intercourse. These can be:

It is worth noting that organic and psychological factors cannot be completely separated from each other. In about 5% of cases, they are closely interrelated.

Effects

Due to the lack of sexual life in a couple, there are usually serious problems in the relationship. Usually they are accompanied by depression, irritation, isolation. A man who is faced with impotence may not go to the doctor for a long time because of embarrassment, instead poisoning his body with numerous folk remedies and pills, which can then adversely affect his health as a whole.

sexual dysfunction

The main sign of the weakening of potency is a decrease in interest in sex, thoughts and fantasies on this topic disappear. The morning erection characteristic of a man’s body disappears or becomes irregular, and it also does not occur during sexual caresses. An erection can also disappear right during sexual intercourse. Sometimes a man may not attach importance to these “bells”, as this does not happen simultaneously.

Due to the huge number of reasons that can lead to violations of sexual function, the diagnosis can only be prescribed by the attending physician after the examination and collection of anamnesis. A few simple rules will help to prevent violations of sexual function.

February 11, 2022 / by Kevin Roberts

Evaluation of the informative value of diagnostic methods in determining the etiology of ED

Diagnostic ED: A large number of research papers on the physiology of erection and the pathophysiology of erectile dysfunction have been published, which have revealed the problem of studying the informativeness of diagnostic methods aimed at identifying the etiology of ED.

Currently, due to the wide choice of laboratory and instrumental diagnostic methods, the question arises about their irrational use, since some of them have insufficient information content and do not have diagnostic significance, and therefore do not play a special role in determining the further tactics of managing patients with erectile dysfunction. At the same time, it should be noted that the strategy for treating ED depends on the effectiveness and timeliness of diagnostic measures, and the delay in finding the causes of erectile disorders negatively affects the effectiveness of therapy.

To establish the etiopathogenetic mechanism of ED development, a comprehensive integrative approach is used, which implies step-by-step laboratory and instrumental studies. However, this does not always make it possible to obtain reliably significant information necessary for making a decision on the further plan of therapeutic and diagnostic measures.

The determination of diagnostic parameters that are highly specific and sensitive in determining the etiology of ED will reduce the frequency of unnecessary diagnostic measures and increase the accuracy of the really necessary diagnostic methods, which means that the optimal therapeutic tactics will be chosen.

Purpose of the study: To evaluate the informativeness of the diagnostic parameters used in determining the etiology of ED.

Materials and methods diagnostic ED

The study involved 465 men who complained about the inability to achieve and maintain an erection sufficient for sexual intercourse. The median age of the patients was 39 (30-49 years). The study did not include patients with cancer, autoimmune, or mental illnesses identified during the examination.

All participants underwent a step-by-step comprehensive diagnosis, including a clinical and anamnestic examination, a questionnaire (according to the questionnaire of the international index of erectile function 15), a physical and laboratory-instrumental examination. The results of a biochemical blood test (total protein, total bilirubin, creatinine, urea, alanine aminotransferase, aspartate aminotransferase, glucose) were evaluated with the determination of lipid (total cholesterol, high-and low-density lipoprotein cholesterol, triglycerides) and hormonal (total testosterone, sex hormone-binding globulin, estradiol, prolactin, and thyroid-stimulating hormone) profiles.

All patients underwent pharmacodopplerographic examination of the vessels of the penis using intracavernous injections of prostaglandin E1 (none of the patients had contraindications to this procedure). Diagnostic parameters such as the peak systolic blood flow rate in the cavernous arteries (Vmax a. cavernosa), the final diastolic blood flow rate in the cavernous arteries (Vend a. cavernosa), the index of resistance of the cavernous arteries, as well as the maximum speed and time of preservation of blood flow in the deep dorsal vein were evaluated.

diagnostic ED

All patients also underwent a non-invasive examination of the endothelial system function using a special EndoPat hardware complex with the determination of the value of the reactive hyperemia index, which allows us to assess the presence or absence of endothelial dysfunction.

Based on the results of the examination, the patients were divided into two groups for a consistent statistical analysis. The first group included 319 (68.6%) men with diagnosed organic forms of ED, the median age was 44 years. The second group included 146 (31.4%) men who had confirmed ED that was not associated with organic factors, the median age was 30 years.

Results

According to the results of the study, diagnostic parameters that are sufficiently informative make it possible to timely identify risk factors and pathological conditions underlying the etiology of ED, avoiding overdiagnosis. Diagnostic parameters that have unsatisfactory information content can be conditionally considered as additional if appropriate clinical data are available.

Through the consistent use of informative diagnostic parameters, it is possible to establish risk factors, as well as concomitant somatic diseases that are associated with the development of organic forms of ED, in order to determine further therapeutic and diagnostic tactics.

December 13, 2021 / by Kevin Roberts

Experience in the use of alpha-lipoic acid in the treatment of erectile disorders in patients with diabetes mellitus

Alpha-lipoic acid in the treatment of erectile: To date, there are more than 250 million patients with diabetes mellitus, a chronic non – communicable disease with a pandemic growth rate, in the world alone. At the same time, about 50% of all patients with diabetes are patients of the most active and working age (40-59 years).

Experts of the International Diabetes Federation predict that the number of such patients will increase by one and a half times by 2025 and reach 380 million, mainly due to type 2 diabetes. Data from control and epidemiological studies conducted by the Endocrinology Research Center from 2002 to 2009 indicate that the real number of patients with diabetes is two to three times higher than the registered one and amounts to about 9 million people.

Alpha-lipoic acid in the treatment of erectile dysfunction

The prevalence of erectile dysfunction – a permanent inability to achieve and maintain an erection sufficient for successful sexual intercourse, among diabetic patients, according to various studies, ranges from 20 to 85%. Having diabetes increases the risk of erectile dysfunction by two to four times compared to healthy men of the same age.

In total, about 75% of men with the disease sooner or later notice erectile dysfunction, while such disorders occur in them much earlier than in healthy men, are more severe and more reduce the quality of life. The age of patients, the duration of the course of diabetes, the severity of metabolic disorders (uncontrolled glycemia, hyperlipidemia), the presence of diabetic neuropathy, retinopathy, nephropathy, macroangiopathy are important risk factors for the development of erectile dysfunction in people with diabetes and no viagra can help here.

The role of alpha-lipoic acid drugs in the treatment of erectile dysfunction

For a long time, various preparations of an endogenous antioxidant – alpha-lipoic acid, which is formed during the oxidative decarboxylation of alpha-keto acids, have been successfully used in practical healthcare in Russia. The antioxidant effect of alpha-lipoic acid is due to the presence of two thiol groups in the molecule, the ability to bind free radicals and free tissue iron and prevent its participation in lipid peroxidation.

The property of normalization of cellular metabolism is realized by direct inactivation of free radicals due to their binding by SH-groups of alpha-lipoic acid. The acid not only has its own antioxidant potential, but also provides powerful support for other antioxidant links in the body. Its protective effect is closely related to homeostasis in the system of glutathione and ubiquinone. Alpha-lipoic acid also enhances the anti-inflammatory effects of glucocorticosteroids. In addition, this acid is similar in pharmacological properties to B vitamins, as a result of which it is able to reduce blood glucose levels (the effect of glucose utilization) and increase the content of glycogen in the liver.

alpha-lipoic acid in the treatment of erectile

Of particular interest are the results of a recent study of the effectiveness of alpha-lipoic acid in patients with type 2 diabetes and erectile dysfunction, conducted at the Research Institute of Urology. Alpha-lipoic acid was administered at a dose of 600 mg / day and the parameters of erectile function, libido, and symptoms of androgen deficiency were evaluated. The study involved 86 men aged 43 to 59 years (mean age 51 years) with compensated (HbA1c < 7%) type 2 diabetes and erectile dysfunction. 52 men of the main group received alpha-lipoic acid. The control group consisted of 34 patients.

The effectiveness of treatment was evaluated 12 weeks after the appointment of alpha-lipoic acid based on the completion of the validated ICEF-5 scale and the questionnaire of age – related symptoms of men (Aging Male Simptoms-AMS). When analyzing the results of the study, the patients of the main group showed a significant increase in the sum of ICEF-5 scores from 18 (13-21) to 22 (20-24) and a decrease in the AMS score from 42 (35-44) to 33 (29-34) compared to the control group, where there were no significant changes in the scores according to the questionnaires.

The researchers believe that taking into account the positive pathogenetic effect of alpha-lipoic acid on the endothelium of the cavernous arteries, as well as on the cavernous nerves, new possibilities for its use in the treatment of erectile dysfunction in patients with DM and other forms of erectile dysfunction, taking into account the general mechanisms of development.

Conclusion

Erectile dysfunction is an urgent problem for patients with diabetes – a widespread worldwide disease with a high growth rate. Pathogenetic therapy of erectile dysfunction in patients of this category necessarily implies compensation for DM and a decrease in the severity of symptoms of peripheral diabetic polyneuropathy.

For a long time, for the treatment of diabetic neuropathy, the administration of various alpha-lipoic acid drugs has been successfully practiced, which reduce the manifestations of oxidative stress – the leading factor in the pathogenesis of diabetes and its complications. The possibility of effective administration of alpha-lipoic acid in erectile dysfunction in patients with DM determines the relevance and prospects of its clinical use.

October 21, 2021 / by Kevin Roberts
Smoking affects potency

How smoking affects potency

Dear smokers, I have bad news for you. In fact, the naked truth that smoking affects potency in a negative way has been known for a long time. You yourself have definitely seen the warning labels and pictures on cigarette packs. Moreover, you may have heard the medical term “nicotine impotence”. Anyway, today I propose to talk about the connection between erectile dysfunction and smoking.

The effect of nicotine on male sexual function

Most men have real phobia of impotence. However, many imagine this diagnosis as a complete loss of erection. Meanwhile, in fact, erectile dysfunction most often manifests itself as insufficient firmness of the penis.

The condition of this male organ depends on a symbiosis of factors, including blood circulation. Obviously, smoking has a negative effect on blood vessels. Thus, smoking affects potency – indirectly and negatively.

First, nicotine causes the blood vessels to constrict. In addition, it provokes a spasm of the vascular walls. This, in turn, affects the arteries of the heart, blood vessels, lungs, as well as the penis. With prolonged abuse of nicotine, the structure of blood vessels and their ability to relax worsen, they lose former firmness and elasticity.

Some studies on the effect of smoking on potency

A number of studies have shown that the negative effects of smoking on blood vessels and sexual function are in most cases reversible. In other words, if you give up the bad habit, you can return to a normal erection over time. However, in order to speed up the process, better use the drugs for erectile dysfunction at the same time.

smoking affects potency

One of the scientific studies has shown that problems with potency attack more than half (53%) of smokers aged 40 to 47 years. By the way, smoking affects potency in different ways. In particular, men may complain of a weak erection, difficulty in maintaining it, early ejaculation, or, conversely, the inability to finish.

Scientists have also found that the likelihood of problems and their intensity correlate with smoking history. Men who smoke one pack of cigarettes a day are 60% more likely to develop impotence than non-smokers. For ex-smokers, the risk is 15% higher than for those who have never abused nicotine. Diagnosed impotence in smokers occurs 30% more often than in people without such bad habits.

Other effects of smoking and factors important for male health

Of course, smoking affects potency, but it also negatively influences the quality indicators of sperm. Smokers have a decrease in sperm count, spermatozoids become less mobile. So, if you want to not only enjoy quality sex, but also become a father, better quit smoking as soon as possible.

However, do not try to focus only on how smoking affects potency. Do not forget that other factors – a sedentary lifestyle, lack of physical activity, unhealthy diet, alcohol abuse, stress, and so on – also negatively affect male sexual power.

August 29, 2021 / by Kevin Roberts

Impotence-causing medicines: A brief guide

Unfortunately, many men, especially with aging, face the problem of poor erection quality. Quite often, this happens due to impotence-causing medicines. With certain diagnosis, patients have to take them, thus risking their sexual health.

Below we will list some commonly used impotence-causing medicines which can trigger the onset of erectile dysfunction. At the same time, please mind that impotence occurs in a minor percentage of patients.

List of impotence-causing medicines

Let us divide the drugs in groups:

  • medicines for the treatment of arterial hypertension, diuretic drugs, centrally acting antihypertensives, α-blockers, β-blockers
  • drugs for the treatment of dyslipidemia (high triglycerides / cholesterol)
  • certain medications to treat heart failure
  • drugs for the treatment of neurological and psychiatric diseases, including lithium salts, haloperidol, chlorpromazine and barbiturates
  • medicines for the treatment of prostatic and endocrinological diseases, corticosteroids
  • certain drugs for gastroenterological diseases
  • drugs for the treatment of inflammatory and degenerative diseases of the osteo-articular system

In particular, such impotence-causing medicines can alter both the function of the hypothalamus-pituitary system and testicular steroidogenesis. Also, they can act by antagonizing the peripheral action of androgens. In any case, better see a doctor who may possibly prescribe you an alternative therapy.

Other risk factors for men

Besides the listed drug groups, mind other potentially harmful substances. For example, men may obtain erectile dysfunction due to drug (cannabis, cocaine, LSD etc.) abuse. In addition, drinking too much alcohol and smoking cigarettes can also aggravate the disorder. Moreover, alcohol abuse often leads to decreased libido and premature ejaculation.

impotence-causing medicines

July 30, 2021 / by Kevin Roberts